All Quiet On The Western Front 2022 2h 27m 7.9
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Background: Altered perceptual processing of signals originating from within the body (i.e., interoceptive dysfunction) has been linked to anxious psychopathology. In a recent pharmaco-fMRI study we showed that individuals with generalized anxiety disorder (GAD) exhibit autonomic hypersensitivity evidenced by elevated heart rates, heightened interoceptive awareness of cardiorespiratory sensations, increased anxiety, and a blunted neural response localized to the ventromedial prefrontal cortex during low level beta-adrenergic stimulation (Teed et al (2022)). Here, we examine whether the peripheral adrenergic modulation of cardiac signals with isoproterenol differentially affected the heartbeat evoked potential (HEP), an electroencephalogram (EEG) marker of neural activity in response to heartbeats, in females with GAD versus healthy comparison females (HC).
Background: Growing up in a neighborhood with high crime rates is associated with sleep disturbances, mental health problems, and altered brain function. Our previous study found that prenatal exposure to neighborhood crime was associated with reduced frontolimbic connectivity in the neonatal brain, partially mediated by maternal psychosocial stress (Brady et al. 2022). It is unknown whether prenatal crime exposure and subsequent neonatal brain changes lead to altered behavior in infancy or beyond. It is plausible that prenatal crime exposure relates to later behavior, as studies in middle childhood and adolescence demonstrate a link between living in a high-crime neighborhood and mental health problems. We hypothesize that prenatal crime exposure will be related to poorer socioemotional outcomes, mediated by both maternal psychosocial stress and neonatal frontolimbic connectivity. 781b155fdc